| 摘要 |
Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent =C- or =N-; W is a divalent radical -CH=CH- or CH<SUB>2</SUB>CH<SUB>2</SUB>-; R<SUB>1</SUB> is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R<SUB>2</SUB> is the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L<SUP>1</SUP>, and X<SUP>1</SUP> are as defined in the claims. |
| 申请人 |
CHROMA THERAPEUTICS LTD.;DAVIDSON, ALAN, HORNSBY;MOFFAT, DAVID, FESTUS, CHARLES;DAY, FRANCESCA, ANN;DONALD, ALASTAIR, DAVID, GRAHAM |
发明人 |
DAVIDSON, ALAN, HORNSBY;MOFFAT, DAVID, FESTUS, CHARLES;DAY, FRANCESCA, ANN;DONALD, ALASTAIR, DAVID, GRAHAM |
