| 摘要 |
FIELD: medicine, oncology, pharmacy. ^ SUBSTANCE: invention relates to drugs and concerns an antitumor composition for injection. Agent comprises derivative of anthracycline possessing the antitumor activity as an active component, and block-copolymer formed by derivative of polyethylene oxide and derivative of polyaspartic acid. The composition comprises additionally saccharide and a base represented by sodium hydrocarbonate, sodium hydrophosphate, sodium citrate and sodium hydroxide with pH value in the range 4-9. Also, invention proposes a composition based on block-copolymer micelles, solution of block-copolymer micelles with pH value in the range 4-9, and a solid composition for injection prepared by drying a micellar solution. Compositions show stability for a prolonged period and possess the improved capacity for repeated dissolving. ^ EFFECT: improved and valuable pharmaceutical properties of preparation. ^ 15 cl, 2 tbl, 10 ex |
