摘要 |
<p>The invention refers to of a compound of the formula (I) wherein R3 and R4 are independently H or OH, and wherein m and n are independently of one another 0, 1 or 2, obtainable from Actinomadura namibiensis (DSM 6313), its use for the treatment of bacterial infections, viral infections and/or pain, and pharmaceutical composition comprising it. The compounds of formula (I) have been defined as labyrinthopeptins and consist of a highly bridged peptidic structure of 18 amino acids containing lanthionine-like residues and alpha disubstituted amino acid analogues. The amino acid sequence is XDWXLWEXCXTGXLFAXC, wherein the two Cys residues form a disulfide bridge and each X independently represents one of the non-natural amino acids involved in the bridging linkages.</p> |
申请人 |
SANOFI-AVENTIS;SEIBERT, GERHARD;VERTESY, LASZLO;WINK, JOACHIM;WINKLER, IRVIN;SUESSMUTH, RODERICH;SHELDRICK, GEORGE;MEINDL, KATHRIN;BROENSTRUP, MARK;HOFFMANN, HOLGER;GUEHRING, HANS;TOTI, LUIGI |
发明人 |
SEIBERT, GERHARD;VERTESY, LASZLO;WINK, JOACHIM;WINKLER, IRVIN;SUESSMUTH, RODERICH;SHELDRICK, GEORGE;MEINDL, KATHRIN;BROENSTRUP, MARK;HOFFMANN, HOLGER;GUEHRING, HANS;TOTI, LUIGI |