OSMOTIC BI-LAYER TABLET

摘要

An osmotic bi-layer tablet for the controlled release of a low-solubility drug comprises an inner core containing a drug-containing layer and a water-swellable layer, and a water-permeable outer coating including at least one delivery port, wherein the drug- containing layer comprises a drug substance, polyethylene oxide polymer having an average molecular weight from about 200,000 to 600,000Da, and an osmogen, and the water-swellable layer comprises polyethylene oxide polymer having a weight average molecular weight of from about 4,000,000 to about 7,000,000Da and a sweller layer strengthening agent.