LIGANDS FOR VIRUS CHANNEL PROTEINS

摘要

Ligands that exert biological effects upon viruses by binding to their membrane-spanning protein components, such as membrane channel M2 in influenza virus, are of great pharmacological significance. The invention disclosed herein provides methods of manufacturing of particles that carry such a channel protein on their surface, and oriented in the same way as in viral and cellular membranes. Also disclosed are methods of making antibodies that bind to the channel protein in the particles and uses of such antibodies for treating infections.