发明名称 EPOTILONE ANALOGUE COMPOSITION IN COMBINATION WITH CHEMOTHERAPEUTIC AGENTS FOR CANCER TREATMENT
摘要 FIELD: organic chemistry, medicine, oncology, pharmacy. ^ SUBSTANCE: invention proposes antitumor agents compositions and their using fro production of antitumor drugs. Compositions comprise a combination of at least chemotherapeutic agent chosen from capecitabine, cetuximab (C225 antibodies), bevacizumab and herceptin with compound of the formula (I): . Proposed combinations and compositions provide achievement of the synergistic anti-tumor effect. ^ EFFECT: valuable medicinal property of compositions. ^ 7 cl, 9 tbl, 13 dwg, 12 ex
申请公布号 RU2321400(C2) 申请公布日期 2008.04.10
申请号 RU20030130377 申请日期 2002.03.05
申请人 BRISTOL-MAERS SKVIBB KOMPANI 发明人 LI FREHNSIS I. F.
分类号 A61K31/41;C07D491/044;A61K31/136;A61K31/166;A61K31/282;A61K31/33;A61K31/335;A61K31/337;A61K31/365;A61K31/366;A61K31/407;A61K31/427;A61K31/436;A61K31/475;A61K31/513;A61K31/519;A61K31/704;A61K31/7052;A61K31/7068;A61K33/24;A61K38/00;A61K39/395;A61K45/00;A61K45/06;A61P1/18;A61P11/00;A61P13/08;A61P13/10;A61P35/00;A61P35/02;A61P35/04;A61P43/00;C07D417/06;C07D493/04 主分类号 A61K31/41
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