| 发明名称 |
Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of PDE4 isozymes |
| 摘要 |
Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of Formula (1.0.0): wherein R<SUP>5 </SUP>and R<SUP>6 </SUP>are taken together to form a moiety of partial Formulas (1.1.1) through (1.1.5): or a pharmaceutically acceptable salt thereof.
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| 申请公布号 |
US7354941(B2) |
申请公布日期 |
2008.04.08 |
| 申请号 |
US20020181416 |
申请日期 |
2002.07.24 |
| 申请人 |
PFIZER PRODUCTS INC. |
发明人 |
MARFAT ANTHONY;CHAMBERS ROBERT JAMES |
| 分类号 |
A61K31/465;A61K31/4439;A61K31/665;A61K31/67;A61K45/00;A61K45/06;A61P1/04;A61P1/16;A61P3/10;A61P7/00;A61P7/06;A61P9/10;A61P9/12;A61P11/00;A61P11/02;A61P11/06;A61P11/08;A61P13/00;A61P13/02;A61P13/08;A61P13/12;A61P17/00;A61P17/04;A61P17/06;A61P17/14;A61P19/02;A61P19/08;A61P19/10;A61P21/00;A61P21/04;A61P25/00;A61P25/14;A61P25/16;A61P25/24;A61P25/28;A61P27/02;A61P29/00;A61P31/10;A61P31/12;A61P31/18;A61P35/00;A61P37/04;A61P37/06;A61P43/00;C07D401/12;C07D401/14;C07D413/12;C07D413/14;C07D417/12;C07D417/14 |
主分类号 |
A61K31/465 |
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