发明名称 |
NANOCRYSTALLINE FORMULATIONS OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) PROTEASE INHIBITORS USING CELLULOSIC SURFACE STABILIZERS AND METHODS OF MAKING SUCH FORMULATIONS |
摘要 |
The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1(HIV-1) and type 2 (HIV-2) protease inhibitors are described.
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申请公布号 |
CA2295588(C) |
申请公布日期 |
2008.04.08 |
申请号 |
CA19982295588 |
申请日期 |
1998.07.09 |
申请人 |
NANOSYSTEMS, L.L.C. |
发明人 |
ROBERTS, MARY E.;ENGERS, DAVID A.;RUDDY, STEPHEN B.;WONG, SUI-MING;LIVERSIDGE, GARY G.;XU, SHUQIAN |
分类号 |
A61K31/341;C12N9/99;A61K9/10;A61K9/14;A61K9/18;A61K9/20;A61K9/51;A61K31/192;A61K31/366;A61K31/427;A61K31/472;A61K31/4725;A61K31/496;A61K31/551;A61K31/635;A61K38/55;A61K45/08;A61K47/38;A61K47/48;A61P31/18;C07K14/81 |
主分类号 |
A61K31/341 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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