| 发明名称 |
Statine derivatives for the treatment of Alzheimer's disease |
| 摘要 |
The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
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| 申请公布号 |
US7354943(B2) |
申请公布日期 |
2008.04.08 |
| 申请号 |
US20050076161 |
申请日期 |
2005.03.08 |
| 申请人 |
PHARMACIA & UPJOHN |
发明人 |
SCHOSTAREZ HEINRICH JOSEF;CHRUSCIEL ROBERT ALAN |
| 分类号 |
A61K31/44;C07D277/20;A61K31/166;A61K31/275;A61K31/426;A61K31/4406;A61P25/16;A61P25/28;A61P43/00;C07C231/02;C07C237/22;C07C253/30;C07C255/13;C07C271/22;C07C315/04;C07C317/18;C07C317/50;C07C319/20;C07C323/59;C07C323/60;C07D213/02;C07D213/82;C07D277/56;C07K5/06 |
主分类号 |
A61K31/44 |
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