发明名称 |
Method of encapsulating metal complex within liposomes |
摘要 |
An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such as <SUP>99m</SUP>Tc and CD is encapsulated, with radiochemical yield and purity enabling practical application. The present invention provides a method of producing a liposome wherein a complex of a short half-life metallic radioactive nuclide and ethylenedicysteine (CD) is encapsulated, which comprises mixing a complex of a short half-life metallic radioactive nuclide and N-[2-(1H-pyrrolylmethyl)]-N'-(4-penten-3-on-2)-ethane-1,2-diamine with an ethylenedicysteine (CD)-encapsulated liposome, and incubating the mixture.
|
申请公布号 |
US7354567(B2) |
申请公布日期 |
2008.04.08 |
申请号 |
US20050503139 |
申请日期 |
2005.02.22 |
申请人 |
BIO MED CORE INCORPORATION |
发明人 |
ARANO YASUSHI;KANEKO EMI;MURAKAMI MASAHIRO |
分类号 |
A61K51/00;A61K51/12;A61M36/14;A61P35/00 |
主分类号 |
A61K51/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|