| 摘要 |
#CMT# #/CMT# Use of compositions containing hyaluronic acid or its salts and Poloxamer 407, is claimed to prepare a drug to fill the scars, wrinkles or irregularities of the skin. #CMT#ACTIVITY : #/CMT# Vulnerary; Dermatological. #CMT#MECHANISM OF ACTION : #/CMT# None given. #CMT#USE : #/CMT# The compositions are useful to prepare a drug to fill the scars, wrinkles or irregularities of the skin i.e. to render plasiticity to the skin (claimed). The drug is useful in plastic surgery. No biological data given. #CMT#ADVANTAGE : #/CMT# The composition is stable and the injection of the composition is easy and less painful. #CMT#PHARMACEUTICALS : #/CMT# Preparation (Claimed): The compositions are prepared by dissolving 0.5-2% of hyaluronic acid and a dispersing agent and a viscous solution of 10-20 wt.% of Poloxamer 407 in a fixed volume of saline buffer solution, and sterilizing the mixture maintained at about 5[deg] C by humid heat. Preferred Composition: The drug contains hyaluronic acid in the form of a polymer having a molecular weight of 1.1 million Daltons and Poloxamer 407 in the form of an aqueous dispersion of 14-18%. #CMT#ADMINISTRATION : #/CMT# Administration of the composition is in the form of intraarticular or subcutaneous injection. |
