IDENTIFICATION OF NON-SMALL CELL LUNG CARCINOMA (NSCLC) TUMORS EXPRESSING PDGFR-ALPHA

摘要

The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRE) is expressed and is driving the disease, and provided methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRE is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFRE-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFRE is expressed, and for determining whether a compound inhibits the progression of a PDGFRE-expressing mammalian NSCLC tumor.