CD47 RELATED COMPOSITIONS AND METHODS FOR TREATING IMMUNOLOGICAL DISEASES AND DISORDERS
摘要
Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.
申请公布号
WO2007133811(A3)
申请公布日期
2008.04.03
申请号
WO2007US12234
申请日期
2007.05.15
申请人
VIRAL LOGIC SYSTEMS TECHNOLOGY CORP.;SMITH, CRAIG, A.;WILEY, STEVEN;KAYKAS, AJAMETE;PROBST, PETER
发明人
SMITH, CRAIG, A.;WILEY, STEVEN;KAYKAS, AJAMETE;PROBST, PETER