RETINOIC ACID DERIVATIVE HAVING ANTI-AGING ACTIVITY AND PREPARATION METHOD THEREOF

摘要

A retinoic acid derivative is provided to exhibit a collagen production effect and a collagenase expression inhibition effect and cause less skin irritation. A method for preparing a retinoic acid derivative includes the steps of: (i) reacting retinoic acid with alkylchloroformate to prepare an anhydride compound represented by the following formula 2; and (ii) reacting the prepared anhydride compound with an amine hydrochloride represented by the following formula 3 to prepare the retinoic acid derivative represented by the following formula 1. In the formulae, R1 is hydrogen, linear or branched C1-7 alkyl or C3-7 cycloalkyl, R2 is hydroxyl, linear or branched C1-7 alkyl substituted by 1-4 hydroxyl groups, or linear branched C1-5 alkyl substituted by hydroxy pyranone, and R3 is C1-7 alkyl.