| 摘要 |
The present invention provides methods of optimizing certain stable liqui d formulations of antibodies that immunospecifically bind to antigens of int erest. Such formulations are suitable for parenteral administration to a sub ject, and exhibit increased stability, low to undetectable levels of aggrega tion, low to undetectable levels of antibody fragmentation/degradation, and very little to no loss of the biological activities of the antibodies, even during long periods of storage. The methods of the invention provide formula tions that offer multiple advantages over formulations produced by non-optim ized methods, including less stringent or more readily available transportat ion and storage conditions, less frequent dosing, and/or smaller dosage amou nts in the therapeutic, prophylactic and diagnostic uses of such formulation s. The invention further provides methods of identifying antibodies exhibiti ng certain phase behaviors such that the antibodies can be formulated by the methods of the invention. Also provided are prophylactic, therapeutic, and diagnostic uses of such antibody formulations.
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