| 摘要 |
The invention relates to new compounds having heptose synthesis inhibitor y properties, of formula (I) or a pharmaceutically acceptable salt, or prodr ug thereof, wherein A is an aryl or heterocycle, optionally substituted by o ne or several identical or different R such as H, C1-C10 alkyl, C1-C10 alkyl -OR1, C1-C10 alkyl-NR1R1, alkoxy, hydroxy, thioalkyl, aryl, heterocycle, hal ogen, nitro, cyano, CO2R1, NR1R1, NR1C(O)R1, C(O)NR1R1, NR1C(S)R1, C(S)NR1R1 , SO2NR1R1, SO2R1, NR1SO2R1, NR1C(O)NR1R1, NR1C(O)OR1, NR1C(S)NR1R1, NR1C(S) OR1, R1C=NOR1, C(O)R1, aryloxy, thioaryl, alkenyl, alkynyl R1 identical or d ifferent is H or C1-C10 alkyl B1, B2, B3 identical or not represent C, N, O, S to form a five-membered aromatic ring wherein from one to three carbon at oms are replaced by a heteroatom selected from S, O, N optionally substitute d by one or several identical or different R such as defined above B4 is C o r N Y is H, C1-C10 alkyl, alkoxy, thio-alkyl, optionally substituted by one or several identical or different R such as defined above W is C, O or N, su bstituted or not by one or several C1-C10 alkyl radicals D is an heterocycle optionally substituted by one or several identical or different R such as d efined above.
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