The present invention provides fusion proteins of Calcitonin with Interleukin 2 that have enhanced biological activity compared to Calcitonin. In particular, the present invention provides the process of preparing and using compositions of the fusion protein of Calcitonin with Interleukin 2. Also provided are calcitonin prodrugs and fusion proteins comprising IL2 and calcitonin that are designed to cleave and release calcitonin and/or interleukin-2 on administration and uses thereof. Compositions for treating cancer comprising said fusion proteins are provided.
