MODULATION OF NKG2D AND METHOD FOR TREATING OR PREVENTING SOLID ORGAN ALLOGRAFT REJECTION

摘要

The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D. The present application also relates to method for treating or preventing solid organ allograft rejection, the method comprising administering an agent that reduces ligand-induced NKG2D activation of cells (such as an antibody that binds NKG2D) and an inhibitor of lymphocyte co-stimulation to a subject in need thereof (such as CTLA4-Ig or LEA29Y)