发明名称 |
DNA METHYLATION AS A TARGET FOR DIAGNOSIS AND TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) |
摘要 |
Global DNA methylation is a predictor of aggressive disease in patients with chronic lymphocytic leukemia. The higher the DNA methylation, the more likely a patient is going to require systemic therapy. Although there is a gradual decline in global DNA methylation with increasing age in normal individuals, the methylation index only decreases by approximately 0.03 per decade. A pilot study was performed in which patients with chronic lymphocytic leukemia were treated with low doses of DNA methylation inhibitors to evaluate if inhibition of DNA methylation can translate into a clinical benefit. Inhibition of DNA methylation was observed to lead to re-expression of tumor suppressors and normal cellular function. At low non-toxic doses of 0.05-0.09 mg per kilogram per day for three days every 28 days, some patients with chronic lymphocytic leukemia were observed to achieve a reduction in circulating leukemia cells. This was observed to correlate with a reduction in global DNA methylation and an alteration in methylation of core histones. |
申请公布号 |
WO2007067695(A3) |
申请公布日期 |
2008.04.03 |
申请号 |
WO2006US46718 |
申请日期 |
2006.12.07 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION;YU, MARGARET;PHILLIPS, JOHN |
发明人 |
YU, MARGARET;PHILLIPS, JOHN |
分类号 |
C12Q1/68;A61P35/02 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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