<p>The present invention provides methods of producing recombinant renalase using a methylotrophic yeast such as Pichia pastoris. The invention provides a method for producing recombinant renalase protein by culturing a Pichia pastoris harboring a renalase coding sequence operably linked to a promoter. The recombinant Pichia pastoris is cultured under conditions that permit or induce expression of the renalase protein. The recombinant renalase protein may then be recovered from cell extracts, from culture medium or culture supernatants. Recombinant renalase produced in accordance with the invention is stable, and abundant amounts of renalase can be produced. The present invention also provides for recombinant forms of renalase, including recombinant vectors and cells containing a renalase coding sequence.</p>
