发明名称 |
INTERLEUKIN-1 MUTEINS LINKED TO VIRUS-LIKE PARTICLES TO TREAT IL-1 ASSOCIATED DISEASES |
摘要 |
<p>The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 mutein. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 mutein linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.</p> |
申请公布号 |
WO2008037504(A1) |
申请公布日期 |
2008.04.03 |
申请号 |
WO2007EP53007 |
申请日期 |
2007.03.29 |
申请人 |
CYTOS BIOTECHNOLOGY AG;BACHMANN, MARTIN;SPOHN, GUNTHER;TISSOT, ALAIN |
发明人 |
BACHMANN, MARTIN;SPOHN, GUNTHER;TISSOT, ALAIN |
分类号 |
A61K39/385;C07K14/545;C12N7/04 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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