| 摘要 |
The present invention relates to a method for identifying a subject at ri sk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of said subject; (b) comp aring the level of said biological marker to a standard level of the same bi ological marker; and (C) determining whether the level of the marker is indi cative of a risk for developing heart failure, wherein the biological marker is Krüppel Like Factor 15 (KLF-15) and/or lysosomal integral membrane prote in-2 (LIMP-2) and/or fragments and/or variants thereof, and/or wherein the b iological marker is a gene coding for KLF15 and/or LIMP-2, and/or fragments and/or variants thereof. The invention further relates to use of the KLF15 a nd/or LIMP-2 protein, and/or the gene coding for KLF15 and/or LIMP2, and/or fragments, and/or variants of said genes and/or proteins, for the preparatio n of a medicament for a prophylactic and/or a therapeutic medicament for pre vention and/or treatment of heart failure.
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