| 摘要 |
PROBLEM TO BE SOLVED: To provide HBV core antigen particles characterized by multiple immunogen specificities. SOLUTION: The HBV core antigen particles are characterized by multiple immunogen specificities. More particularly, the HBV core antigen particles comprises immunogens, epitopes, or other related structures, crosslinked thereto by ligands which are HBV capsid-binding peptides that selectively bind to HBV core protein. Such particles may be used as delivery systems for a diverse range of immunogenic epitopes, including the HBV capsid-binding peptides. Mixtures of different immunogens and/or capsid-binding peptide ligands may be crosslinked to the same HBV core particle. Such resulting multicomponent or multivalent HBV core particles may be advantageously used in therapeutic and prophylactic vaccines and compositions, as well as in diagnostic compositions and methods using the same. COPYRIGHT: (C)2008,JPO&INPIT
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