发明名称 COMBINATION PREPARATION, PARTICULARLY FOR TREATING PROSTATE CANCER
摘要 Composition (A) comprising an inhibitor (I) of 5alpha -reductase; an estrogen receptor beta -agonist (II) and an inhibitor (III) of prostate-specific antigen (PSA), for simultaneous or sequential administration, is new. ACTIVITY : Cytostatic. Results for the effects of individual components on the growth of prostatic cancer cells are given but no results for the combination of (I)-(III). MECHANISM OF ACTION : Inhibition of 5alpha -reductase and PSA, and agonism of the estrogen receptor, resulting in reduced bioavailability of insulin-like growth factor -1 (which has a proliferation-stimulating effect) and reduced secretion of vascular endothelial growth factor (so inhibiting formation of new blood vessels).
申请公布号 EP1904018(A2) 申请公布日期 2008.04.02
申请号 EP20060762663 申请日期 2006.07.17
申请人 BIONORICA RESEARCH GMBH 发明人 JARRY, HUBERTUS;WUTTKE, WOLFGANG;SEIDLOVA-WUTTKE, DANA;POPP, MICHAEL, A.
分类号 A61K6/00 主分类号 A61K6/00
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