发明名称 |
COMBINATION PREPARATION, PARTICULARLY FOR TREATING PROSTATE CANCER |
摘要 |
Composition (A) comprising an inhibitor (I) of 5alpha -reductase; an estrogen receptor beta -agonist (II) and an inhibitor (III) of prostate-specific antigen (PSA), for simultaneous or sequential administration, is new. ACTIVITY : Cytostatic. Results for the effects of individual components on the growth of prostatic cancer cells are given but no results for the combination of (I)-(III). MECHANISM OF ACTION : Inhibition of 5alpha -reductase and PSA, and agonism of the estrogen receptor, resulting in reduced bioavailability of insulin-like growth factor -1 (which has a proliferation-stimulating effect) and reduced secretion of vascular endothelial growth factor (so inhibiting formation of new blood vessels). |
申请公布号 |
EP1904018(A2) |
申请公布日期 |
2008.04.02 |
申请号 |
EP20060762663 |
申请日期 |
2006.07.17 |
申请人 |
BIONORICA RESEARCH GMBH |
发明人 |
JARRY, HUBERTUS;WUTTKE, WOLFGANG;SEIDLOVA-WUTTKE, DANA;POPP, MICHAEL, A. |
分类号 |
A61K6/00 |
主分类号 |
A61K6/00 |
代理机构 |
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代理人 |
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地址 |
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