发明名称 |
COMPOSITION AND METHOD FOR ENHANCING TRANSPORT ACROSS BIOLOGICAL MEMBRANES |
摘要 |
Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention includes a method for enhancing transport of a selected compound across a biological membrane, wherein a biological membrane is contacted with a conjugate containing a biologically active agent that is covalently attached to a transport polymer. In one embodiment, the polymer consists of from 6 to 25 subunits, at least 50 % of which contain a guanidino or amidino sidechain moiety. The polymer is effective to impart to the attached agent a rate of trans-membrane transport across a biological membrane that is greater than the rate of trans-membrane transport of the agent in non-conjugated form.
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申请公布号 |
CA2291074(C) |
申请公布日期 |
2008.04.01 |
申请号 |
CA19982291074 |
申请日期 |
1998.05.21 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
ROTHBARD, JONATHAN B.;WENDER, PAUL A. |
分类号 |
A61K47/48;A61K31/711;A61K38/00;A61K47/42;A61K48/00;A61P43/00;C07B61/00;C07D305/14 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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