发明名称 |
Tumor antigens and CTL clones isolated by a novel procedure |
摘要 |
The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
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申请公布号 |
US7351409(B2) |
申请公布日期 |
2008.04.01 |
申请号 |
US20040753158 |
申请日期 |
2004.01.07 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
CHAUX PASCAL;LUITEN ROSALIE;DEMOTTE NATHALIE;DUFFOUR MARIE-THERESE;LURQUIN CHRISTOPHE;TRAVERSARI CATIE;STROOBANT VINCENT;CORNELIS GUY R.;BOON-FALLEUR THIERRY;VAN DER BRUGGEN PIERRE;SCHULTZ ERWIN;WARNIER GUY |
分类号 |
A01N63/00;G01N33/50;A61K35/26;A61K38/00;A61K38/04;A61K39/00;A61P35/00;C07K7/06;C07K14/47;C07K14/705;C07K14/82;C07K19/00;C12N5/06;C12N5/08;C12N5/10;C12N15/09;C12Q1/02;C12Q1/06;G01N33/15;G01N33/53;G01N33/574 |
主分类号 |
A01N63/00 |
代理机构 |
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代理人 |
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地址 |
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