发明名称 |
Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof |
摘要 |
Pharmaceutically acceptable liposome-encapsulated busulphan formulations for parenteral administration are provided, as well as such formulations furthermore comprising glutathione and/or at least one glutathione precursor and a process for manufacture of the preparations. The formulations are stable, have improved biodistribution and significantly reduced side effects over those produced by oral administration or parenteral administration of free drug. The formulations are useful as part of stem cell and/or bone marrow transplant conditioning regimens. A method of treatment of a mammal by use of such formulations.
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申请公布号 |
US7351427(B2) |
申请公布日期 |
2008.04.01 |
申请号 |
US20030425980 |
申请日期 |
2003.04.30 |
申请人 |
BUSULIPO AB |
发明人 |
HASSAN ZUZANA;HASSAN MOUSTAPHA |
分类号 |
A61K9/127;A61K31/255;A61K38/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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