PYRAZOLO-PYRIMIDINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS

摘要

COMPUNDS HAVING THE FORMULA (I),AND PHARMACEUTICALLY ACCEPTABLE SALTS OR PRODRUGS,THEREOF AE USEFUL AS KINASE INHIBITORS,WHEREIN Y IS -C(=O)NR1-,-NR1C(=O)-,-NR1C(=O)NR1-,-NR1SO2-,-SO2NR1-,-C(=O)-,-OC(=O)- OR -CO2-;B IS ALKYL,SUBSTITUTED ALKYL,ALKENYL,SUBSTITUED ALKENYL,HYDROXY,ALKOXY,ARYL,CYCLOALKYL,HETEROARYL,AND HETEROCYCLO;OR WHEN Y IS -C(=O)NR1-,B ALSO MAY BE SELECTED FROM -C(=O)R8 -C(=O)NR8R9, AND -CO2R8;R1 IS HYDROGEN,C1-4ALKYL,OR SUBSTITUTED C1-4ALKYL; R2 IS HYDROGEN OR C1-4ALKYL;R3 IS HYDROGEN,METHYL,PERFLUOROMETHYL,HYDROXY,METHOXY,HALOGEN,CYANO,NH2,OR NH(CH3);AND R4,R5,R6,R7,R8,AND R9 ARE AS DEFINED IN THE SPECIFICATION.