Anti-osteopontin antibody and use thereof

摘要

Disclosed is an anti-osteopontin antibody which can inhibit the binding between an integrin recognizing the site of the amino acid sequence RGD and a thrombin-cleaved N-terminal fragment of osteopontin, and which can also inhibit the binding between an integrin recognizing the site of the amino acid sequence SVVYGLR or SLAYGLR and a thrombin-cleaved N-terminal fragment of osteopontin. The antibodies are useful for treating autoimmune diseases, rheumatism and rheumatoid arthritis.