Synthetic GHRH analogues of 29 amino acids or more

摘要

A GHRH analogue or a pharmaceutically acceptable salt which is able to stimulate secretion or synthesis of growth hormone in a mammal. The GHRH analogue or pharmaceutically acceptable salt has an in vitro potency index substantially higher than the in vitro potency index of a native hGHRH1-29 and have a formula Tyr-D-Ala2 -Asp-Ala-Ile-Phe-Thr-Asn-Ser-D-Tyr-10 -Arg-Lys-Val-Leu-D-Ala15 -Gln-Leu-Ser-Ala-ARg-Lys-Lys22-Leu-Gln-Asp-Ile-Met-Ser-Arg-A30-NH2 , wherein A30 is a bond or any amino acid sequence of 1 up to 15 residues. Also disclosed is a pharmaceutical composition comprising the GHRH analogues and the use of the analogues in the preparation of a drug in the treatment of GH deficiency-related conditions.