Immunotherapeutic compositions and methods for the treatment of moderately to well-differentiated prostrate cancers

摘要

Disclosed is an immunotherapeutic composition comprising activated, isolated autologous antigen presenting cells (APCs) of a patient diagnosed with prostrate cancer having a moderate to well differentiated cancer grade and a Gleason score of 7 or less, wherein the APCs are stimulated by exposure ex vivo to a fusion protein composed of human granulocyte macrophage colony stimulating factor (huGM-CSF) and a polypeptide having at least 80% amino acid sequence identity to the sequence identified by SEQ ID NO:1 (huPAP).