New process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate

摘要

Disclosed is a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulphonate, a key intermediate of quinolone antibiotics. According to the process, the total number of steps has been reduced to 3-4 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants is eliminated.