Novel method for synthesising (2S, 3AS, 7AS)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis

摘要

Disclosed is the production of (2S, 3aS, 7aS)-perhydroindole-2-carboxylic acid derivatives of formula (I) which comprises reacting 1-(1-cyclohexenyl)pyrrolidine with a N-protected 3-iodoalanine derivative, deprotecting the amino group, cyclizing and dehydrating the product, catalytically hydrogenating the product at 1-30 bar, and optionally deprotecting or reprotecting the acid group.