摘要 |
This invention relates to a new process for preparation of enantiomerically pure dapoxetine or an acid addition salt thereof i.e. S(+)-N,N-dimethyl-2-[2-(naphthalenyl oxy)ethyl]benzenemethanamine hydrochoride, a potent serotonin re-uptake inhibitor (SSRI), which comprises resolving racemic (±)-dapoxetine i.e. (±)- N,N-dimethyl-2-[2- (naphthalenyloxy)ethyl] benzene methanamine with a chiral acid so as to obtain salt of the chiral acid and (+)-dapoxetine, substantially free from (-)-dapoxetine. |
申请人 |
CADILA HEALTHCARE LIMITED;DAVE, AXAY, MUKUNDRAY;PATEL, DHIMAT, JASUBHAI;KUMAR, RAJIV;DWIVEDI, SHRIPRAKASH, DHAR |
发明人 |
DAVE, AXAY, MUKUNDRAY;PATEL, DHIMAT, JASUBHAI;KUMAR, RAJIV;DWIVEDI, SHRIPRAKASH, DHAR |