Cell delivery matrices and methods for facilitating local delivery of adipose derived endothelial cells to a target tissue, body cavity, or joint are described. The cell delivery matrix may be a three-dimensional matrix scaffold comprising fibrin derived from the patient's own body. The cell delivery matrix may be biocompatible and semi-permeable. The cell delivery matrix used in the methods of the invention may be comprised of any degradable, bioabsorbable or non-degradable, biocompatible polymer. Regenerative therapies comprising implanting in the subject cell delivery matrices localizing adipose derived endothelial cells are described. The cell delivery matrices maintain the adipose derived endothelial cells at the target for a therapeutically effective amount of time. The adipose derived endothelial cells can be allogenic or syngenic to the subject. The endothelial cells may be delivered alone or in combination with other therapeutic agents.
申请公布号
WO2008036209(A2)
申请公布日期
2008.03.27
申请号
WO2007US20048
申请日期
2007.09.13
申请人
TISSUE GENESIS;BOLAND, EUGENE, D.;WILLIAMS, STUART, K.;KOSNIK, PAUL, E.
发明人
BOLAND, EUGENE, D.;WILLIAMS, STUART, K.;KOSNIK, PAUL, E.