摘要 |
The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus ('CHIPS'), the polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:1. Preferably, the polypeptide is a CHIPS variant wherein one or more of the following amino acids is modified: N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 and G112. In a preferred embodiment, the polypeptide is less immunogenic hi humans than the wildtype CHIPS protein. The invention further provides methods of making and using such variant CHIPS polypeptides. |
申请人 |
ALLIGATOR BIOSCIENCE AB;SMITH, STEPHEN, EDWARD;FUREBRING, CHRISTINA;VAN STRIJP, JOHANNES;HAAS, PETRUS, JOHANNES, ANDREAS;ROSEN, ANNA;HARALDSSON, KARIN;GUSTAFSSON, ERIKA;SCHULTZ, LENA;VAN KESSEL, CORNELIS |
发明人 |
FUREBRING, CHRISTINA;VAN STRIJP, JOHANNES;HAAS, PETRUS, JOHANNES, ANDREAS;ROSEN, ANNA;HARALDSSON, KARIN;GUSTAFSSON, ERIKA;SCHULTZ, LENA;VAN KESSEL, CORNELIS |