| 摘要 |
This invention relates to compounds of the formula (I): or a pha rmaceutically acceptable salt thereof, wherein: R1, R2, R3, R4, A and E are each as described herein or a pharmaceutically acceptable salt, and composit ions containing such compounds and the method of treatment and the use, comp rising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal dise ase, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryn gopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NS AID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zolli.pi.ger-Ellison syndrome, non-erosive reflux dise ase (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia , hypersalivation, airway disorders or asthma.
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