STABILIZED INTERFERON COMPOSITION

摘要

PROBLEM TO BE SOLVED: To provide a protein pharmacological composition (comprising an IFN-βcomposition). SOLUTION: A stabilized pharmaceutical formulations comprising the IFN-βand highly purified mannitol are provided. The highly purified mannitol stabilizes the compositions by reducing the formation of IFN-βadducts in comparison with IFN-βformulated with mannitol that has not been highly purified. Methods for increasing the stability of IFN-βor a variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided. COPYRIGHT: (C)2008,JPO&INPIT