发明名称 |
5(S)-(2'-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN AND ITS PREPARATION AND USE FOR THE TREATMENT OF CANCER |
摘要 |
A 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2'-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
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申请公布号 |
US2008076791(A1) |
申请公布日期 |
2008.03.27 |
申请号 |
US20070753432 |
申请日期 |
2007.05.24 |
申请人 |
DR.REDDY'S LABORATORIES LIMITED;DR.REDDY'S LABRATORIES, INC. |
发明人 |
AKELLA VENKATESWARLU;ALIKUNJU SHANAVAS;REKA AJAYA K.;MULLANGI RAMESH;SIRISILLA RAJU;DUVVURI SUBRAHMANYAM;RAJAGOPAL SRIRAM |
分类号 |
A61K31/436;A61P35/00;C07D491/22 |
主分类号 |
A61K31/436 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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