发明名称 |
COMPOSITIONS AND METHODS FOR ENHANCING THE EFFICACY OF IL-2 MEDIATED IMMUNE RESPONSES |
摘要 |
Compositions and methods directed to enhancing the effectiveness of IL-2 in stimulating the immune system is disclosed. According to one method, an antagonist directed against the CD25 subunit of the high-affinity IL-2 receptor complex is administered in conjunction with IL-2. The CD25 antagonist may be an anti-CD25 antibody. According to another method, an anti-IL-2 antibody is administered in conjunction with IL-2. In another method, a mutant IL-2 with diminished ability to bind the CD25 subunit of the high-affinity IL-2 receptor complex is administered. In another method, an CD4 antagonist is administered in conjunction with IL-2 in order to stimulate the immune system. |
申请公布号 |
WO2008003473(A3) |
申请公布日期 |
2008.03.27 |
申请号 |
WO2007EP05904 |
申请日期 |
2007.07.04 |
申请人 |
MERCK PATENT GMBH;GILLIES, STEPHEN, D. |
发明人 |
GILLIES, STEPHEN, D. |
分类号 |
C12N15/62;A61K39/395;C07K14/55 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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