| 摘要 |
Cell delivery matrices and methods for facilitating local delivery of adi pose derived endothelial cells to a target tissue, body cavity, or joint are described. The cell delivery matrix may be a three-dimensional matrix scaff old comprising fibrin derived from the patient's own body. The cell delivery matrix may be biocompatible and semi-permeable. The cell delivery matrix us ed in the methods of the invention may be comprised of any degradable, bioab sorbable or non-degradable, biocompatible polymer. Regenerative therapies co mprising implanting in the subject cell delivery matrices localizing adipose derived endothelial cells are described. The cell delivery matrices maintai n the adipose derived endothelial cells at the target for a therapeutically effective amount of time. The adipose derived endothelial cells can be allog enic or syngenic to the subject. The endothelial cells may be delivered alon e or in combination with other therapeutic agents. |
