PREVENTION OF ATHEROSCLEROSIS AND UNDESIRED BLOOD CLOTTING BY REDUCING VON WILLEBRAND FACTOR
摘要
This invention provides methods and compositions for treating and preventing atherosclerosis other undesired blood clotting. The methods for treating and preventing atherosclerosis and related conditions involve administering to a mammal an agent that reduces activity of an ST3Gal IV sialyltransferase, which results in enhanced clearance of von Willebrand Factor (vWF) from the mammal.
申请公布号
WO0122921(A3)
申请公布日期
2008.03.27
申请号
WO2000US26550
申请日期
2000.09.27
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MARTH, JAMEY, D.;ELLIES, LESLEY, G.