NANOGEL CONTRAST AGENTS FOR OPTICAL MOLECULAR IMAGING

摘要

The present invention relates to a nanogel comprising a polymer network of repetitive, crosslinked, ethyl enically unsaturated monomers of Formula (I): wherein X is a water-soluble monomer containing ionic or hydrogen bonding moieties; Y is a water-soluble macromonomer containing repetitive hydrophilic units bound to a polymerizeable ethylenically unsaturated group; Z is a multifunctional crosslinking monomer; m ranges from 50-90 mol%; n ranges from 2-30 mol%; and o range from 1-15 mol% and a method for preparing a nanogel comprising preparing a header composition of a mixture of monomers X, Y, and Z, and a first portion of initiators in water; preparing a reactor composition of a second portion initiators, surfactant, and water; bringing the reactor composition to the polymerization temperature; holding the reactor composition at the polymerization temperature, and adding the header composition to the reactor composition to form a nanogel of Formula I.