METHOD FOR THE SYNTHESIS OF HEXAHYDROFURO (2, 3-B) FURAN-3-OL COMPOUNDS

摘要

The present invention relates to a method for the synthesis of enantiomerically and diastereomerically enriched hexahydro-furo[2,3-b]furan-3-ol compounds by aldol coupling of two suitable O-protected hydroxyaldehydes and subsequent removal of the protecting groups and (optionally simultaneous) cyclization of the resulting aldol compound and subsequent isolation of the desired compounds. The resulting composition can be further diastereomerically enriched through the intermittent acylation or aroylation of the compound and further optionally using a stereoselective hydrolyzing enzyme.