Apicomlex vaccine strains of a family of Sarcocystidae

摘要

Mutant strain (A) of an Apicomplexa of the family Sarcocystidae contains mutations that inactivate both of the adhesins MIC1 and MIC3. An independent claim is also included for a vaccine that contains (A). ACTIVITY : Protozoacide. MECHANISM OF ACTION : Vaccine. Mice were injected intraperitoneally with 20 tachyzoites of T. gondii in which both MIC1 and MIC3 were inactivated, then 1 month later challenged with 70 cysts of the cystogenic strain 76K. Practically no cerebral cysts were formed in the vaccinated animals (99.9 % protection).