发明名称 |
A PROCESS FOR PREPARATION OF METHYL-(+)-(S)-ALPHA-(2-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)-ACETIC ACID METHYL ESTER OR SALTS THEREOF HAVING HIGHER CHIRAL PURITY AND PRODUCTS THEREOF |
摘要 |
<p>A process for preparation of Methyl-(+)-(S)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester or salts thereof [clopidogrel or salts thereof of Formula (I)] having higher chiral purity and products thereof is provided. A process for purification of the compound prepared is also provided to enhance its efficacy by enhancing its optical rotation and chiral purity. In Formula (I), R is selected from a group comprising alkyl, alkoxy, hydroxy, amine etc., and R1 is selected from the group comprising C1-4 alkyl, C1-4 alkoxy, hydroxy, nitro & halogen. The particular salt of interest of the present invention is the hydrogen sulfate of compound of the Formula (I), wherein R and R1 are—OCH3 and chloro-group at position 2 respectively.</p> |
申请公布号 |
EP1902058(A2) |
申请公布日期 |
2008.03.26 |
申请号 |
EP20060832291 |
申请日期 |
2006.07.07 |
申请人 |
RPG LIFE SCIENCES LIMITED |
发明人 |
SRIVASTAVA, ANITA RANJAN;PAWAR, PRASHANT PANDURANG;POOJARI, KRISHNA ANAND;PATIL, PRAVIN CHAITRAM;DALVI, RAJIV RAMCHANDRA |
分类号 |
C07D495/04;A61K31/4365 |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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