BACKBONE CYCLIZED MELANOCORTIN STIMULATING HORMONE (alpha;MSH) ANALOGA

摘要

Novel backbone cyclized peptides which are a-melanocortin stimulating hormone (aMSH) analogs, having improved Melanocortin-4 receptor agonist activity are disclosed. The backbone cyclized peptide analogs disclosed possess unique and superior properties over other analogs, such as metabolic stability, increased oral bioavailability, improved intestinal permeability and pharmacological activity in-vivo. Pharmaceutical compositions comprising the backbone cyclized aMSH analogs, and methods of using such compositions for the treatment of metabolic disorders including obesity are also disclosed. ® KIPO & WIPO 2008