Int6 PROTEIN INVOLVED IN HYPOXIA STRESS INDUCTION AND USE THEREOF

摘要

The present inventors successfully identified an HIF2± binding factor, Int6, which has binding activity to the HIF2±, as a factor involved in hypoxic stress response that promotes angiogenesis. Furthermore, the present inventors discovered that Int6 suppresses HIF2±-mediated transcription of hypoxic stress-responsive genes by interacting with HIF2±. Substances that inhibit Int6 expression or its function promote angiogenesis by enhancing the activity of HIF2± to promote transcription of hypoxic stress-responsive genes, and are expected to have therapeutic effects for various vascular diseases including myocardial infarction.