发明名称 TRAIL RECEPTOR 2 POLYPEPTIDES AND ANTIBODIES.
摘要 <p>Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand ("TRAIL") Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.</p>
申请公布号 MX2008002735(A) 申请公布日期 2008.03.26
申请号 MX20080002735 申请日期 2006.08.28
申请人 AMGEN INC. 发明人 XIAO FENG;IAN FOLTZ;XIAO-DONG YANG;BRIAN GLINIAK;SHARON WONG-MADDEN;ALISON FITCH;STEPHEN FOSTER;RANDALL R. KETCHEM
分类号 C07K16/28;A61K39/00;C12N15/13 主分类号 C07K16/28
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