STABLE FIXED-DOSE UNITARY FORMULATIONS CONTAINING TENOFOVIR, A SURFACTANT, EFAVIRENZ AND EMTRICITABINE

摘要

In accordance with this invention a novel pharmaceutical product containing efavirenz, emtricitabine and tenofovir DF are provided as a multicomponent unitary oral dosage form, component 1 comprising tenofovir DF (and, optionally, emtricitabine) and component 2 comprising efavirenz, wherein components 1 and 2 are in a stabilizing configuration. In preferred embodiments component 1 is made by dry granulation. ® KIPO & WIPO 2008